Not on immunotherapy myself (MSI-stable), but always interested in hearing experiences as it’s a potential future option if other markers arise. Glad your husband is tolerating it relatively well, Karen. The fatigue sounds significant though.

Also MSI-stable, so no firsthand immunotherapy experience, but sending positive thoughts for continued success with Keytruda for your husband, Karen! Fatigue is just part of the cancer battle, regardless of treatment type, it seems.

My Lynch Syndrome means I’m MSI-High, so immunotherapy is often effective if cancer develops (thankfully hasn’t). Very interested in hearing real-world experiences like your husband’s, Karen. Thanks for sharing. Hope the fatigue stays manageable.

Echoing others, great that Keytruda is working. Just wanted to add, make sure you report any new or worsening symptom to the oncology team promptly, even if it seems minor. As William noted, irAEs can affect almost any organ system and early intervention is key.

Karen, glad the Keytruda is working well overall. Immunotherapy side effects are generally different from chemo – they stem from the immune system being activated and potentially attacking healthy tissues (immune-related adverse events or irAEs). Common ones include fatigue, rash, itching, diarrhea/colitis, pneumonitis (lung inflammation), hepatitis (liver), endocrinopathies (thyroid, adrenal issues). Most are mild/moderate but some can be severe. Monitoring thyroid function, liver enzymes, etc., is standard. Did they check his thyroid levels? Fatigue can sometimes be linked to hypothyroidism.