My husband is Stage 4, MSI-High, and has been on Keytruda (pembrolizumab) for several months now. Generally, it’s going well, much better than chemo side effects would likely be. Main issue is fatigue and occasional mild rash. Curious about others’ experiences with immunotherapy (Keytruda, Opdivo, etc.) - what side effects did you encounter? Anything unexpected pop up later? How severe were they?

Not on immunotherapy myself (MSI-stable), but always interested in hearing experiences as it’s a potential future option if other markers arise. Glad your husband is tolerating it relatively well, Karen. The fatigue sounds significant though.