My husband is Stage 4, MSI-High, and has been on Keytruda (pembrolizumab) for several months now. Generally, it’s going well, much better than chemo side effects would likely be. Main issue is fatigue and occasional mild rash. Curious about others’ experiences with immunotherapy (Keytruda, Opdivo, etc.) - what side effects did you encounter? Anything unexpected pop up later? How severe were they?

Thanks William. Yes, they check his bloodwork regularly, including thyroid (TSH). It’s been normal so far, but good reminder to keep monitoring. The list of potential ‘itis’ issues is daunting, but good to be aware of.