My husband is Stage 4, MSI-High, and has been on Keytruda (pembrolizumab) for several months now. Generally, it’s going well, much better than chemo side effects would likely be. Main issue is fatigue and occasional mild rash. Curious about others’ experiences with immunotherapy (Keytruda, Opdivo, etc.) - what side effects did you encounter? Anything unexpected pop up later? How severe were they?

Echoing others, great that Keytruda is working. Just wanted to add, make sure you report any new or worsening symptom to the oncology team promptly, even if it seems minor. As William noted, irAEs can affect almost any organ system and early intervention is key.