Thanks for sharing, William! I use Signatera and find the tech fascinating, albeit anxiety-inducing. Improved sensitivity is great news, but also potentially means picking up clinically insignificant blips? Always a double-edged sword. Did the article mention specificity improvements too?
For me, yes, the potential benefit outweighs the anxiety, but it’s a close call some days! The plan if positive is immediate, high-res scans (PET/CT, maybe MRI) to try and locate the source, followed by discussion of treatment (likely chemo, possibly targeted therapy depending on what’s found). Knowing there is a plan helps manage the ‘what if’.
My oncologist at [Major Cancer Center] uses Signatera routinely for surveillance post-Stage 3 treatment (alongside scans/CEA). It’s personalized to my tumor’s specific mutations found at surgery.
Every 3 months currently. The wait for results is always nail-biting. Trying to trust the process and my oncology team’s interpretation.